The SLOW5 format provides the framework for efficient, parallelizable analysis of nanopore signal data for any intended application. SLOW5 reading and writing is managed by efficient software application programming interfaces (APIs) for both the C (slow5lib) and Python (pyslow5) languages (Methods). This facilitates integration of SLOW5 into third-party software, including with existing packages, by replacing the existing FAST5 API. Notably, just 70 lines of code were required for adoption of SLOW5 by the third-party software Sigmap22, compared to 2,600 lines of code for FAST5 access within the same tool. This shows the simplicity of the SLOW5 API, which is fully open source and not dependent on the HDF5 library required to read FAST5. Along with the simple, intuitive structure of SLOW5 format, this will support active and open software development for nanopore data analysis.
I had a similar error after a clean install of Visual Studio 2017 and had to do the following to get it to automatically restore missing NuGet packages successfully. In VS, go to "Tools > Options > NuGet Package Manager > Package Sources", and ensure the appropriate package sources show and are checked.
Fast Report 4.0.11 Full Source 64 Bit
DOWNLOAD: https://tinurli.com/2vzlzu
Paint.NET v3.5.11 - released on August 17th, 2013The primary goal of this update is preparing for the v4.0 release: previous versions of Paint.NET will not be able to offer the v4.0 update. Also included are some small fixes and performance improvements that have been ported over from the v4.0 codebase. Fixed: The Gaussian Blur effect was incorrectly calculating alpha values for non-opaque pixels.
Improved performance of the Sharpen effect by about 25%
Improved performance of the Median effect by about 30%
Improved performance of the Fragment effect by about 40%
Improved performance of the Unfocus effect by about 100%
Reduced memory usage when many selection manipulation operations are in the history/undo stack (the undo data is now saved to disk)
The built-in updater now supports upgrading to paint.net 4.0 (when it's available)
Paint.NET v3.5.10 - released on October 9th, 2011This update fixes some broken shortcut keys for the View -> Actual Size command.Fixed: Ctrl+Shift+A now works again as a shortcut for View -> Actual Size (broken in 3.5.9)
Fixed: Ctrl+0 still works for View -> Actual Size even if 10 or more images are open (broken in 3.5.9, it would switch to the 10th image).
Paint.NET v3.5.9 - released on October 1st, 2011This update improves the "Auto-Detect" bit-depth feature, and fixes a few small issues.Improved: The "Auto-detect" bit-depth setting for PNG, BMP, and TGA now also determines which bit-depth to use based on which one produces the smallest file size, as well as which ones can save the image without losing fidelity.
Improved: You can now use Ctrl+0 as a shortcut key for View -> Actual Size, in addition to Ctrl+Shift+A and Ctrl+Alt+0.
Fixed: Some text in the DirectDraw Surface (DDS) Save Configuration UI was not being loaded.
Fixed: Some DirectDraw Surface (DDS) files authored with other software (e.g. Unreal 2004) could not be loaded.
Fixed: In some rare circumstances, clicking on the Save button in the toolbar would crash.
Fixed: The Korean translation has been added back in, with the help of Bing machine translation to cover the few remaining strings that were untranslated.
Paint.NET v3.5.8 - released on March 5th, 2011This update fixes some issues with the fault-tolerant save feature introduced in 3.5.7.Fixed: Saving to a folder that has been moved or renamed will display an error instead of crashing (regression from 3.5.6)
Fixed: Saving to a Sharepoint site will now work (regression from 3.5.6)
Fixed: Saving to a file that is marked as read only will now give an error instead of crashing (regression from 3.5.6)
Fixed: General reliability and correctness improvements to fault-tolerant saving
Paint.NET v3.5.7 - released on February 20th, 2011This update improves reliability of saving, further improves Copy/Paste functionality, and fixes some other miscellaneous bugs.Saving an image is now fault-tolerant. If there is an error or crash while saving, the original file will be left alone.
Worked around a bug in some plugins that are incorrectly using the built-in Gaussian Blur effect. For example, Sharpen+. Now they won't crash.
Fixed a bug with Edit->Paste into New Image, where the new image would be 1 pixel too wide or tall, as reported at -paste-problem/
Fixed a bug with the Rectangle Select tool and Fixed Ratio selection, which would be off by 1 pixel, as reported at -croppig-by-fixed-ratio-is-inexact
When pasting an image from Paint.NET into Paint.NET, it will be a little smarter about where it puts the image. Previously, if the location wasn't within the viewport, it would be placed at the top-left corner of the viewport. Now it will find the nearest point along the edge of the viewport to place the image.
The EXIF rotation ("orientation") metadata is now discarded when opening an image, which was causing aggravation with images that could then never be reoriented correctly using Image->Rotate
The EXIF metadata for JPEG thumbnail data are now correctly discarded.
Fixed a handful of memory leaks.
Fixed a typo in the Italian translation. In the setup wizard it was referring to "Pain.NET" (woops)
Paint.NET v3.5.6 - released on November 18th, 2010This update fixes several issues related to copy-paste, improves performance and quality for a few adjustments, and fixes a data loss bug.When pasting an image, Paint.NET will be smarter about ensuring it is placed within the area that has been scrolled/zoomed to.
Improved the performance and quality of the Curves and Hue/Saturation adjustments.
Some minor improvements to memory usage, which should help out a few scenarios on 32-bit systems.
Fixed: If a JPEG was loaded that had an embedded ICC profile, and was then saved as an 8-bit or 24-bit PNG, then the resulting file would be corrupt (32-bit PNG worked fine though).
Fixed: 16-bit TGAs no longer load with the red and blue channels swapped.
Fixed: Copy-paste from a Remote Desktop session will no longer be 'shifted' by 3 pixels.
Fixed: Copy-paste from Internet Explorer, Firefox, or Chrome should preserve alpha/transparency.
Fixed: Copying from Paint.NET and pasting into Windows Live Writer should now work.
Fixed: Taking a full-screen screenshot with Print Screen on a multimonitor system, where those monitors don't form a simple rectangle, will now fill the 'gap area' with transparent instead of black. (Example: two monitors of the same size, one of which is rotated by 90 degrees)
Fixed: If Paint.NET is opened without specifying an image to open, and then the default image is modified and saved, then Paint.NET will no longer close it upon opening another one. This was causing data loss if that default image had layers, and was then saved in a format that did not support layers (anything other than .PDN).
Fixed: Some systems were showing 'red X' thumbnails for .PDN files in Windows Explorer, instead of the real thumbnail.
Fixed: The EXIF "Creation Software" saved along with images is no longer localized. This prevents certain languages from seeing "Paint.NET ????? v3.5.6" in the image properties (metadata).
Paint.NET v3.5.5 - released on April 25th, 2010This update fixes a bug when saving 8-bit images, improves layer composition and Gaussian Blur performance, and is now updated to support the new .NET Framework 4.0 in some cases.Fixed the bug where saving as 8-bit PNG/GIF/BMP wasn't always working, usually with larger images.
Improved the performance of the Gaussian Blur effect by 30-40%.
Improved the performance of all the layer blending modes by 15-30%.
Improved the performance of zooming with the mouse wheel on dual-core Intel Atom systems.
Updated to support .NET 4.0 if no other version of .NET is installed.
Reduced download size from 4.8MB down to 3.5MB.
Fixed a small error in the Chinese translation.
Please note that the system requirements have been updated. For Windows XP, you must now have Service Pack 3 (SP3) installed; SP2 is no longer supported. For Windows Vista, you must now have Service Pack 1 installed.
Paint.NET v3.10 Released: August 23rd, 2007This release adds two new effects originally written by David Issel ("BoltBait"), support for theDDS filetype originally written by Dean Ashton, as well as many small bug fixes and some visual fit and finish.New: Soften Portrait effect, by David Issel, .
New: Ink Sketch effect, by David Issel, .
New: DirectDraw Surface (DDS) file format support, by Dean Ashton, . Improved from the original source code by optimizing the DXT compression library ("Squish") to take advantage of multiple cores / processors.
New: "Paint.NET Search", available from the Help menu (shortcut key is Ctrl+E), allows you to search for Paint.NET help, forum posts, tutorials, plugins, and other related material: (Note: This feature is only available in English.)
Improved: Visual fit-and-finish for the Layers window.
Improved: Visual fit-and-finish for the close / 'X' button on image thumbnails.
Improved: Small (about 5-10%) performance improvements for some effects such as Oil Painting, Frosted Glass, and Gaussian Blur.
Improved: Increased max brush size to 500, as per forum members request.
Improved: Expanded list of available font sizes up through 288.
Changed: The keyboard shortcut key for the Color Picker is now 'k'. This makes it so that the toolbar option, "After click: Switch to previous tool", is not useless for those using the keyboard shortcuts.
Fixed: In some cases, undoing an action that removed a layer would result in the un-removed layer not showing up until you resized the Layers window ("ghost layers").
Fixed: Pressing F1 from the main window no longer launches the online help in two browser tabs.
Fixed: Adding a new layer now adds it above the currently active layer, instead of at the very top of the layer list.
Fixed: Merge Down now activates the merged layer instead of the one above it.
Fixed: In Vista, clicking on a URL link from the installer will no longer launch the web browser with inherited, elevated privileges.
Fixed: Pressing Ctrl+[ no longer cancels out of drawing a line/curve, but instead decreases the brush size by 5 as expected.
Fixed: Ctrl+clicking on the brush size +/- buttons now changes the brush size in increments of 5.
Fixed: Save Configuration dialog would "creep downward" from its last position every time it was opened again.
Fixed: TGA codec now saves the # of alpha bits to the image descriptor byte. This was causing some other applications to load TGA files saved with Paint.NET as solid black images.
Fixed: Clicking the 'X' to close the Layer Properties dialog was not reverting changes made to the layer while the dialog was open.
Fixed: Installation will not proceed unless Paint.NET is closed, and will also not allow Paint.NET to be opened until installation is completed. This helps to ensure a fully coherent and complete installation or update.
Fixed: If a file failed to open, and there were no open images, and the user pressed either the Zoom In or Zoom Out toolbar buttons, then Paint.NET would crash.
Fixed: In Vista, it was possible to crash the Save As dialog by typing a filename that was too long.
Fixed: In Vista, it was possible to crash the updater if you let the UAC prompt time-out.
Fixed: It was possible to crash Paint.NET on some systems by clicking on a tool in the Tools window while the "Save As" dialog was open.
v3.08 Released: June 1st, 2007This is mostly a service release that fixes some bugs, while also improving keyboard / accessibility cues for some dialogs.Fixed: Pasting an image from Office 2003 applications now works (e.g. Excel 2003 graphs).
Fixed: Some dialogs were not indicating which command button was the default. These buttons now have a highlight to indicate which one will be activated if the user presses Enter or Space.
Fixed: Some minor keyboard navigation issues with task dialogs
Fixed: Performance issue with the File->Acquire submenu taking a long time to appear
Fixed: Window activation issue when the Print wizard was finished / closed
Fixed: Crash when there was 1 image open and the user pressed Ctrl+Q and then Ctrl+W
Fixed: Minor performance issue if the user had 1 modified image open and then canceled the "Save changes?" dialog
Fixed: Misbehaving filetype factory implementations (plugins) will no longer cause a crash
v3.07 Released: May 8th, 2007This update enhances the Line/Curve tool, significantly reduces the download size, and fixes some bugs related to opening and saving files in Windows Vista.New: Line/Curve tool has been enhanced to allow drawing arrowheads, and to draw with various dashed- and dotted- styles.
New: Image tab thumbnails now have an indicator if the respective image has unsaved changes (an orange asterisk is shown).
Improved: The Save Configuration dialog (choose JPEG quality, etc.) now allows you to maximize it. It also remembers its relative location and size.
Changed: The help file / documentation is now hosted online. This has reduced the download size by more than 3 MB, and will also allow us to provide translations without ballooning the size of the download (each language would have added between 2 and 4MB).
Changed: The "image list button" (downward triangle) is also shown when only 1 image is open (it used to only display if 2 or more images were open). This is being done for the sake of consistency.
Fixed: Some operations would reset the selected layer to the first/lowest layer. This selection is now preserved.
Fixed: The Image->Rotate commands no longer hang if a selection was active.
Fixed: Several problems have been fixed within our implementation surrounding the new Vista Open/Save dialogs. This includes: opening an image from an http:// source, opening images from a digital camera that is not mapped to a file system path (such as a drive letter), the Save dialog not always prompting you about overwriting an existing file, and many corner cases that previously caused crashes.
v3.05 Released: March 29th, 2007This is a minor update that adds a new effect, improves certain parts of the user interface, and fixes a few minor bugs.New: Pencil Sketch effect
New: In Windows Vista, the new-style Save/Open dialogs are used. Among other things, this enables Search functionality.
Changed: The View->Units, Image->Flip, Image->Rotate, and Layers->Flip submenus have been "flattened" (their commands were moved out into the View, Image, Image, and Layers menus respectively)
Improved: Download size reduced by about 300 KB by using PNGOUT
Improved: Some uses of confusing "MessageBox" style dialogs have been changed to a much friendlier "TaskDialog" style interface
Improved: When changing the language, Paint.NET can now restart itself automatically
Improved: Better performance for Move Selected Pixels tool for quad-core systems. This issue is documented and explained here, -net-many-core-performance-scaling-analyzed.aspx
Removed: The "Clear History" button has been removed because it was not very useful
Fixed: Sometimes the Colors window would get "lost" between sessions of Paint.NET
Fixed: Stack-overflow crash when using certain effects, such as Gaussian Blur, on very large images with certain settings (such as a 200 pixel radius)
Fixed: When cancelling the multi-image Unsaved Changes dialog, the input focus was sometimes confused
Changed: Renamed PdnLib.dll to PaintDotNet.Core.dll
Fixed: Very rare race condition in background thumbnail renderer
v3.01 Released: February 26th, 2007 -DownloadThis is a small update that fixes a few bugs that have been found since 3.0 was released. 2ff7e9595c
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